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Fusion Science and Technology
Researchers report fastest purification of astatine-211 needed for targeted cancer therapy
Astatine-211 recovery from bismuth metal using a chromatography system. Unlike bismuth, astatine-211 forms chemical bonds with ketones.
In a recent study, Texas A&M University researchers have described a new process to purify astatine-211, a promising radioactive isotope for targeted cancer treatment. Unlike other elaborate purification methods, their technique can extract astatine-211 from bismuth in minutes rather than hours, which can greatly reduce the time between production and delivery to the patient.
“Astatine-211 is currently under evaluation as a cancer therapeutic in clinical trials. But the problem is that the supply chain for this element is very limited because only a few places worldwide can make it,” said Jonathan Burns, research scientist in the Texas A&M Engineering Experiment Station’s Nuclear Engineering and Science Center. “Texas A&M University is one of a handful of places in the world that can make astatine-211, and we have delineated a rapid astatine-211 separation process that increases the usable quantity of this isotope for research and therapeutic purposes.”
The researchers added that this separation method will bring Texas A&M one step closer to being able to provide astatine-211 for distribution through the Department of Energy’s Isotope Program’s National Isotope Development Center as part of the University Isotope Network.
Details on the chemical reaction to purify astatine-211 are in the journal Separation and Purification Technology.
S. E. Sharapov, L.-G. Eriksson, A. Fasoli, G. Gorini, J. Källne, V. G. Kiptily, A. A. Korotkov, A. Murari, S. D. Pinches, D. S. Testa, P. R. Thomas
Fusion Science and Technology | Volume 53 | Number 4 | May 2008 | Pages 989-1022
Technical Paper | Special Issue on Joint European Torus (jet) | dx.doi.org/10.13182/FST08-A1745
Articles are hosted by Taylor and Francis Online.
Studies establishing key phenomena and developing diagnostics for energetic particle physics, which are essential for the next step burning plasma experiments such as the International Thermonuclear Experimental Reactor (ITER), have been performed at the Joint European Torus (JET). Experiments have demonstrated clear self-heating of deuterium-tritium (D-T) plasma by alpha particles as a maximum in electron temperature at an optimum mixture of 60 ± 20% tritium. The change in electron temperature produced by alpha heating, Te(0) = 1.3 ± 0.23 keV, was as expected from classical heating, whereas the heating of thermal ions was higher than expected from reference deuterium discharges. Alfvén eigenmodes were stable in the highest fusion performance D-T plasmas, in agreement with the modeling. Systematic studies on the existence and properties of Alfvén eigenmodes with external antenna driving and detecting Alfvén eigenmodes are presented. The formation of fuel ion tails due to alpha-particle knock-on effects is described as derived from neutral particle analyzer and neutron emission spectrometry in D-T experiments. The gamma-ray diagnostics are shown to measure profiles and energy distribution functions of high-energy ions and alpha particles. Time- and space-resolved gamma-ray images demonstrated for the first time the possibility of measuring several types of energetic ions simultaneously. The novel technique of detecting unstable Alfvén eigenmodes with interferometry is found to be superior in detecting core-localized Alfvén eigenmodes.