The initiation of the Global Nuclear Energy Partnership includes nuclear-based transmutation devices to recycle the spent fuel. Fusion can offer an alternative to the use of fast reactors for the transmutation of actinides. At a modest fusion power of 20 MW, a Z-Pinch driven sub-critical blanket can burn actinides and produce power. Several engineering issues have been examined: the effect of the sub-critical blanket and its internal fission neutrons on tritium breeding, radiation damage to structure, energy deposition and extraction, and chamber activation. Our initial assessment indicates the Z-Pinch could be an attractive option for burning actinides, but special attention should be paid to the challenging engineering issues.