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Latest News
Researchers report fastest purification of astatine-211 needed for targeted cancer therapy
Astatine-211 recovery from bismuth metal using a chromatography system. Unlike bismuth, astatine-211 forms chemical bonds with ketones.
In a recent study, Texas A&M University researchers have described a new process to purify astatine-211, a promising radioactive isotope for targeted cancer treatment. Unlike other elaborate purification methods, their technique can extract astatine-211 from bismuth in minutes rather than hours, which can greatly reduce the time between production and delivery to the patient.
“Astatine-211 is currently under evaluation as a cancer therapeutic in clinical trials. But the problem is that the supply chain for this element is very limited because only a few places worldwide can make it,” said Jonathan Burns, research scientist in the Texas A&M Engineering Experiment Station’s Nuclear Engineering and Science Center. “Texas A&M University is one of a handful of places in the world that can make astatine-211, and we have delineated a rapid astatine-211 separation process that increases the usable quantity of this isotope for research and therapeutic purposes.”
The researchers added that this separation method will bring Texas A&M one step closer to being able to provide astatine-211 for distribution through the Department of Energy’s Isotope Program’s National Isotope Development Center as part of the University Isotope Network.
Details on the chemical reaction to purify astatine-211 are in the journal Separation and Purification Technology.
M. P. Mauldin, A. L. Greenwood, M. N. Kittelson, C. H. Shearer, J. N. Smith, Jr., D. M. Woodhouse
Fusion Science and Technology | Volume 49 | Number 4 | May 2006 | Pages 842-845
Technical Paper | Target Fabrication | dx.doi.org/10.13182/FST06-A1211
Articles are hosted by Taylor and Francis Online.
Fast ignition is a concept that is being actively investigated in the HED community. The fast ignition targets described here are highly precise targets composed of a small glow discharge polymer (GDP) shell (~860 m diameter) mounted on a gold hyperboloid tipped cone. The process of creating these targets is composed of several steps. The first step consists of machining a copper cone that is then plated with a layer of gold approximately 120 m thick. Next, a hole is machined in a hollow GDP shell that will later be mounted on the gold gone. After the hole of this shell has been measured, the coated cone is machined to shape and to include a shelf so that the shell will sit at the desired location in relation to the tip of the cone. Finally, the copper mandrel is etched away from the gold and the target is assembled with the shell glued into place. At every step of this process, parts must be made and kept within tight specifications to meet the target requirements, not the least of which is that after assembly the shell center must be a specified distance from the gold cone tip with a tolerance of less than 10 m.
