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Researchers report fastest purification of astatine-211 needed for targeted cancer therapy
Astatine-211 recovery from bismuth metal using a chromatography system. Unlike bismuth, astatine-211 forms chemical bonds with ketones.
In a recent study, Texas A&M University researchers have described a new process to purify astatine-211, a promising radioactive isotope for targeted cancer treatment. Unlike other elaborate purification methods, their technique can extract astatine-211 from bismuth in minutes rather than hours, which can greatly reduce the time between production and delivery to the patient.
“Astatine-211 is currently under evaluation as a cancer therapeutic in clinical trials. But the problem is that the supply chain for this element is very limited because only a few places worldwide can make it,” said Jonathan Burns, research scientist in the Texas A&M Engineering Experiment Station’s Nuclear Engineering and Science Center. “Texas A&M University is one of a handful of places in the world that can make astatine-211, and we have delineated a rapid astatine-211 separation process that increases the usable quantity of this isotope for research and therapeutic purposes.”
The researchers added that this separation method will bring Texas A&M one step closer to being able to provide astatine-211 for distribution through the Department of Energy’s Isotope Program’s National Isotope Development Center as part of the University Isotope Network.
Details on the chemical reaction to purify astatine-211 are in the journal Separation and Purification Technology.
J. L. Kaae, D. M. Woodhouse
Fusion Science and Technology | Volume 49 | Number 4 | May 2006 | Pages 838-841
Technical Paper | Target Fabrication | dx.doi.org/10.13182/FST06-A1210
Articles are hosted by Taylor and Francis Online.
The corners on hohlraums can plate at different rates than the hohlraum body during electrolytic deposition of gold on the mandrel used to form the hohlraum shape. The diameter of the mandrel, the radius of the corner, the current density, and whether the corner is convex or concave are factors that influence the plating rate in the corner. These effects are described in this paper.
