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Researchers report fastest purification of astatine-211 needed for targeted cancer therapy
Astatine-211 recovery from bismuth metal using a chromatography system. Unlike bismuth, astatine-211 forms chemical bonds with ketones.
In a recent study, Texas A&M University researchers have described a new process to purify astatine-211, a promising radioactive isotope for targeted cancer treatment. Unlike other elaborate purification methods, their technique can extract astatine-211 from bismuth in minutes rather than hours, which can greatly reduce the time between production and delivery to the patient.
“Astatine-211 is currently under evaluation as a cancer therapeutic in clinical trials. But the problem is that the supply chain for this element is very limited because only a few places worldwide can make it,” said Jonathan Burns, research scientist in the Texas A&M Engineering Experiment Station’s Nuclear Engineering and Science Center. “Texas A&M University is one of a handful of places in the world that can make astatine-211, and we have delineated a rapid astatine-211 separation process that increases the usable quantity of this isotope for research and therapeutic purposes.”
The researchers added that this separation method will bring Texas A&M one step closer to being able to provide astatine-211 for distribution through the Department of Energy’s Isotope Program’s National Isotope Development Center as part of the University Isotope Network.
Details on the chemical reaction to purify astatine-211 are in the journal Separation and Purification Technology.
H. L. Wilkens, A. V. Hamza, A. Nikroo, N. E. Teslich
Fusion Science and Technology | Volume 49 | Number 4 | May 2006 | Pages 809-812
Technical Paper | Target Fabrication | dx.doi.org/10.13182/FST06-A1205
Articles are hosted by Taylor and Francis Online.
The current point design for ignition targets for the National Ignition Facility has a beryllium ablator. As Be is essentially impermeable to hydrogen, conceptually the shell will be filled by boring through the shell with a laser, then attaching a fill-tube. Examination of focused ion beam (FIB) technology is under way as an alternative to laser drilling. Holes of 40, 20, and 15 m diameter have been successfully ion milled through a 47 m thick Be layer. These holes are clean, though take several hours to make, and the geometry is limited by the aspect ratio of the depth to the diameter of the hole. Work was also done to investigate the possibility of using a FIB to create a counter-bore for the insertion and attachment of a fill-tube in a Be shell which has a pre-existing hole. Because the FIB can be controlled to sub-micron scales, the counter-bore can be easily centered on the through-hole and the side-walls and base of the counter-bore can be made very smooth. Finally, a proof-of-principle experiment was made to show that a Be wire could be attached to an in-situ micromanipulator and then be placed inside the counter-bore.