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Fusion Science and Technology
Researchers report fastest purification of astatine-211 needed for targeted cancer therapy
Astatine-211 recovery from bismuth metal using a chromatography system. Unlike bismuth, astatine-211 forms chemical bonds with ketones.
In a recent study, Texas A&M University researchers have described a new process to purify astatine-211, a promising radioactive isotope for targeted cancer treatment. Unlike other elaborate purification methods, their technique can extract astatine-211 from bismuth in minutes rather than hours, which can greatly reduce the time between production and delivery to the patient.
“Astatine-211 is currently under evaluation as a cancer therapeutic in clinical trials. But the problem is that the supply chain for this element is very limited because only a few places worldwide can make it,” said Jonathan Burns, research scientist in the Texas A&M Engineering Experiment Station’s Nuclear Engineering and Science Center. “Texas A&M University is one of a handful of places in the world that can make astatine-211, and we have delineated a rapid astatine-211 separation process that increases the usable quantity of this isotope for research and therapeutic purposes.”
The researchers added that this separation method will bring Texas A&M one step closer to being able to provide astatine-211 for distribution through the Department of Energy’s Isotope Program’s National Isotope Development Center as part of the University Isotope Network.
Details on the chemical reaction to purify astatine-211 are in the journal Separation and Purification Technology.
J. F. Hund, R. R. Paguio, C. A. Frederick, A. Nikroo, M. Thi
Fusion Science and Technology | Volume 49 | Number 4 | May 2006 | Pages 669-675
Technical Paper | Target Fabrication | dx.doi.org/10.13182/FST06-A1184
Articles are hosted by Taylor and Francis Online.
A variety of silica, metal oxide, and metal doped aerogels are being developed for use as laser target materials. Silica aerogels have been produced with controlled densities as low as 5 mg/cc, and have been produced as bulk molds. Recently, 100 mg/cc small beads and hollow shells have also been fabricated using microencapsulation techniques. Metal oxide aerogels such as tantalum oxide (Ta2O5) and tin oxide (SnO2) are two other low-density materials that have been fabricated. Aerogels with embedded metal particles are also of interest and several methods for producing these composite aerogels are being explored. Each method limits excessive aggregation of the metal so that the end product has a uniform loading of small metal particles. Ion implantation is being investigated as another method that allows more control of the metal doping. With ion implantation the metal dopant can be placed in a narrow distribution beneath the surface of an aerogel, and initial results of 1 MeV Au- implanted in 67 mg/cc SiO2 are described.