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Fusion Science and Technology
Researchers report fastest purification of astatine-211 needed for targeted cancer therapy
Astatine-211 recovery from bismuth metal using a chromatography system. Unlike bismuth, astatine-211 forms chemical bonds with ketones.
In a recent study, Texas A&M University researchers have described a new process to purify astatine-211, a promising radioactive isotope for targeted cancer treatment. Unlike other elaborate purification methods, their technique can extract astatine-211 from bismuth in minutes rather than hours, which can greatly reduce the time between production and delivery to the patient.
“Astatine-211 is currently under evaluation as a cancer therapeutic in clinical trials. But the problem is that the supply chain for this element is very limited because only a few places worldwide can make it,” said Jonathan Burns, research scientist in the Texas A&M Engineering Experiment Station’s Nuclear Engineering and Science Center. “Texas A&M University is one of a handful of places in the world that can make astatine-211, and we have delineated a rapid astatine-211 separation process that increases the usable quantity of this isotope for research and therapeutic purposes.”
The researchers added that this separation method will bring Texas A&M one step closer to being able to provide astatine-211 for distribution through the Department of Energy’s Isotope Program’s National Isotope Development Center as part of the University Isotope Network.
Details on the chemical reaction to purify astatine-211 are in the journal Separation and Purification Technology.
R. A. London, B. J. Kozioziemski, M. M. Marinak, G. D. Kerbel, D. N. Bittner
Fusion Science and Technology | Volume 49 | Number 4 | May 2006 | Pages 608-615
Technical Paper | Target Fabrication | dx.doi.org/10.13182/FST06-A1174
Articles are hosted by Taylor and Francis Online.
Infrared heating has been demonstrated as an effective technique to smooth solid hydrogen layers inside transparent cryogenic inertial confinement fusion capsules. Control of the first two Legendre modes of the fuel thickness perturbations using two infrared beams injected into a hohlraum was predicted by modeling and experimentally demonstrated. In the current work, we use coupled ray tracing and heat transfer simulations to explore a wider range of control of long scale length asymmetries. We demonstrate several scenarios to control the first four Legendre modes in the fuel layer using four beams. With such a system, it appears possible to smooth both short and long scale length fuel thickness variations in transparent indirect drive inertial confinement fusion targets