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Fusion Science and Technology
Researchers report fastest purification of astatine-211 needed for targeted cancer therapy
Astatine-211 recovery from bismuth metal using a chromatography system. Unlike bismuth, astatine-211 forms chemical bonds with ketones.
In a recent study, Texas A&M University researchers have described a new process to purify astatine-211, a promising radioactive isotope for targeted cancer treatment. Unlike other elaborate purification methods, their technique can extract astatine-211 from bismuth in minutes rather than hours, which can greatly reduce the time between production and delivery to the patient.
“Astatine-211 is currently under evaluation as a cancer therapeutic in clinical trials. But the problem is that the supply chain for this element is very limited because only a few places worldwide can make it,” said Jonathan Burns, research scientist in the Texas A&M Engineering Experiment Station’s Nuclear Engineering and Science Center. “Texas A&M University is one of a handful of places in the world that can make astatine-211, and we have delineated a rapid astatine-211 separation process that increases the usable quantity of this isotope for research and therapeutic purposes.”
The researchers added that this separation method will bring Texas A&M one step closer to being able to provide astatine-211 for distribution through the Department of Energy’s Isotope Program’s National Isotope Development Center as part of the University Isotope Network.
Details on the chemical reaction to purify astatine-211 are in the journal Separation and Purification Technology.
Géraldine Moll, Philippe Baclet, Michel Martin
Fusion Science and Technology | Volume 49 | Number 4 | May 2006 | Pages 574-580
Technical Paper | Target Fabrication | dx.doi.org/10.13182/FST49-574
Articles are hosted by Taylor and Francis Online.
This paper is an update of the thermal and hydrodynamic simulations of cryogenic target for the laser MegaJoule (LMJ). Depending on the kind of study, 2-D axi-symmetric or 3-D models are used for those numerical simulations with FLUENT, a Computational Fluid Dynamics (CFD) code.Results show the response of the hohlraum assembly and the DT ice layer profile to sinusoidal modulation of the temperature of the cooling rings. aWe have also calculated that no change in the DT ice was observed with variations up to +/-2 mK on thermal shroud. Results of flux absorption during laser alignment are reported here.Taking in account the cavity real geometric configuration, the seven gas-areas cavity appears to be the most effective to counteract convection effects. Other ways to counteract those effects have been explored like heating modulation in the central area on the outer surface of the gold cavity, or uniform heating in this area with auxiliary heating on the lower cooling ring. More, the thermal response of DT ice when it is submitted to a quenching (in order to obtain the LMJ target gas density specification) is shown here.