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Fusion Science and Technology
Researchers report fastest purification of astatine-211 needed for targeted cancer therapy
Astatine-211 recovery from bismuth metal using a chromatography system. Unlike bismuth, astatine-211 forms chemical bonds with ketones.
In a recent study, Texas A&M University researchers have described a new process to purify astatine-211, a promising radioactive isotope for targeted cancer treatment. Unlike other elaborate purification methods, their technique can extract astatine-211 from bismuth in minutes rather than hours, which can greatly reduce the time between production and delivery to the patient.
“Astatine-211 is currently under evaluation as a cancer therapeutic in clinical trials. But the problem is that the supply chain for this element is very limited because only a few places worldwide can make it,” said Jonathan Burns, research scientist in the Texas A&M Engineering Experiment Station’s Nuclear Engineering and Science Center. “Texas A&M University is one of a handful of places in the world that can make astatine-211, and we have delineated a rapid astatine-211 separation process that increases the usable quantity of this isotope for research and therapeutic purposes.”
The researchers added that this separation method will bring Texas A&M one step closer to being able to provide astatine-211 for distribution through the Department of Energy’s Isotope Program’s National Isotope Development Center as part of the University Isotope Network.
Details on the chemical reaction to purify astatine-211 are in the journal Separation and Purification Technology.
W. R. Meier, W. J. Hogan
Fusion Science and Technology | Volume 49 | Number 3 | April 2006 | Pages 532-541
Technical Paper | Fast Ignition | dx.doi.org/10.13182/FST06-A1165
Articles are hosted by Taylor and Francis Online.
Using a simple inertial fusion energy (IFE) power plant economic model, it is demonstrated that there are several potential advantages of an IFE power plant based upon fast ignition targets compared with one based upon central ignition targets. The fast ignition version can have a lower cost of electricity (COE) at the same output power, and a smaller fast ignition plant can have the same COE as a larger central ignition plant. This paper also considers the chamber issues raised by using fast ignition targets. Some direct-drive chamber concepts must be larger for cone-focus fast ignition targets because of the increase in the X-ray output. On the other hand, the use of fast ignition hohlraum targets may allow the use of thick-liquid-wall chambers, bringing the benefits of a smaller chamber and containment building, smaller amounts of hazardous waste, and a faster and cheaper development path. However, many technology issues need resolution before these benefits can become a reality.