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Fusion Science and Technology
Researchers report fastest purification of astatine-211 needed for targeted cancer therapy
Astatine-211 recovery from bismuth metal using a chromatography system. Unlike bismuth, astatine-211 forms chemical bonds with ketones.
In a recent study, Texas A&M University researchers have described a new process to purify astatine-211, a promising radioactive isotope for targeted cancer treatment. Unlike other elaborate purification methods, their technique can extract astatine-211 from bismuth in minutes rather than hours, which can greatly reduce the time between production and delivery to the patient.
“Astatine-211 is currently under evaluation as a cancer therapeutic in clinical trials. But the problem is that the supply chain for this element is very limited because only a few places worldwide can make it,” said Jonathan Burns, research scientist in the Texas A&M Engineering Experiment Station’s Nuclear Engineering and Science Center. “Texas A&M University is one of a handful of places in the world that can make astatine-211, and we have delineated a rapid astatine-211 separation process that increases the usable quantity of this isotope for research and therapeutic purposes.”
The researchers added that this separation method will bring Texas A&M one step closer to being able to provide astatine-211 for distribution through the Department of Energy’s Isotope Program’s National Isotope Development Center as part of the University Isotope Network.
Details on the chemical reaction to purify astatine-211 are in the journal Separation and Purification Technology.
H. Habara, P. A. Norreys, R. Kodama, C. Stoeckl, V. Yu. Glebov
Fusion Science and Technology | Volume 49 | Number 3 | April 2006 | Pages 517-531
Technical Paper | Fast Ignition | dx.doi.org/10.13182/FST06-A1164
Articles are hosted by Taylor and Francis Online.
In recent fast ignitor research, neutron measurements have become increasingly important not only to understand the ultraintense laser-plasma interaction physics associated with ion acceleration and energy transport processes in dense plasmas but also the characterization of the plasma temperature in integrated experiments, as summarized in this paper. New technologies that are relevant to the next-generation integrated fast ignition experiments are also reviewed. These will become increasingly important in the next few years as second-generation multikilojoule petawatt facilities come online and the detection environment becomes increasingly hostile, particularly if, as anticipated, the generated neutron fluxes begin to approach energy breakeven conditions.