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Fusion Science and Technology
Researchers report fastest purification of astatine-211 needed for targeted cancer therapy
Astatine-211 recovery from bismuth metal using a chromatography system. Unlike bismuth, astatine-211 forms chemical bonds with ketones.
In a recent study, Texas A&M University researchers have described a new process to purify astatine-211, a promising radioactive isotope for targeted cancer treatment. Unlike other elaborate purification methods, their technique can extract astatine-211 from bismuth in minutes rather than hours, which can greatly reduce the time between production and delivery to the patient.
“Astatine-211 is currently under evaluation as a cancer therapeutic in clinical trials. But the problem is that the supply chain for this element is very limited because only a few places worldwide can make it,” said Jonathan Burns, research scientist in the Texas A&M Engineering Experiment Station’s Nuclear Engineering and Science Center. “Texas A&M University is one of a handful of places in the world that can make astatine-211, and we have delineated a rapid astatine-211 separation process that increases the usable quantity of this isotope for research and therapeutic purposes.”
The researchers added that this separation method will bring Texas A&M one step closer to being able to provide astatine-211 for distribution through the Department of Energy’s Isotope Program’s National Isotope Development Center as part of the University Isotope Network.
Details on the chemical reaction to purify astatine-211 are in the journal Separation and Purification Technology.
R. Kodama, P. A. Norreys, Y. Sentoku, R. B. Campbell
Fusion Science and Technology | Volume 49 | Number 3 | April 2006 | Pages 316-326
Technical Paper | Fast Ignition | dx.doi.org/10.13182/FST06-A1151
Articles are hosted by Taylor and Francis Online.
A reentrant cone concept for efficient heating of high-density plasmas has been studied as an advanced fast ignition scheme. The roles of the reentrant cone, as indicated by particle-in-cell (PIC) code simulations and confirmed by basic experiments, are reviewed, particularly the efficient collection and guidance of the laser light into the cone tip and the direction of the energetic electrons into the high-density region. It has been shown that the energetic electrons converge to the tip of the cone as a result of the surface electron flow guided by self-generated quasi-static magnetic fields and electrostatic sheath fields. As a result, the energetic electron density at the tip is locally greater than the case of using an open geometry such as a normal flat foil target. Using these advantageous properties of the reentrant cone, efficient fast heating of imploded high-density plasmas has been demonstrated in integrated fast ignition experiments. A hybrid PIC code (LSP) has been used to understand the relativistic electron beam thermalization and subsequent heating of highly compressed plasmas. The simulation results are in reasonable agreement with the integrated experiments. Anomalous stopping appears to be present and is created by the growth and saturation of an electromagnetic filamentation mode that generates a strong back-electromagnetic force impeding energetic electrons.