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Fusion Science and Technology
Researchers report fastest purification of astatine-211 needed for targeted cancer therapy
Astatine-211 recovery from bismuth metal using a chromatography system. Unlike bismuth, astatine-211 forms chemical bonds with ketones.
In a recent study, Texas A&M University researchers have described a new process to purify astatine-211, a promising radioactive isotope for targeted cancer treatment. Unlike other elaborate purification methods, their technique can extract astatine-211 from bismuth in minutes rather than hours, which can greatly reduce the time between production and delivery to the patient.
“Astatine-211 is currently under evaluation as a cancer therapeutic in clinical trials. But the problem is that the supply chain for this element is very limited because only a few places worldwide can make it,” said Jonathan Burns, research scientist in the Texas A&M Engineering Experiment Station’s Nuclear Engineering and Science Center. “Texas A&M University is one of a handful of places in the world that can make astatine-211, and we have delineated a rapid astatine-211 separation process that increases the usable quantity of this isotope for research and therapeutic purposes.”
The researchers added that this separation method will bring Texas A&M one step closer to being able to provide astatine-211 for distribution through the Department of Energy’s Isotope Program’s National Isotope Development Center as part of the University Isotope Network.
Details on the chemical reaction to purify astatine-211 are in the journal Separation and Purification Technology.
R. R. Freeman, D. Batani, S. Baton, M. Key, R. Stephens
Fusion Science and Technology | Volume 49 | Number 3 | April 2006 | Pages 297-315
Technical Paper | Fast Ignition | dx.doi.org/10.13182/FST06-A1150
Articles are hosted by Taylor and Francis Online.
This paper reviews the physics of extremely high current propagation in dense materials. We consider explicitly the problem of the generation of high-current, high-particle energy propagation arising from laser ionization in otherwise neutral targets. The paper concentrates upon the recent experimental results of measurements of the distribution of the laser-generated fast electrons, both in space as well as in energy. The emphasis is primarily to put into physical context the growing number of experimental observations under widely varying conditions. Little or no effort is made to summarize the theoretical or modeling work because of manuscript size limitations; however, when possible, experimental observations are tied to relevant attempts to model the observed behavior. The fundamental conclusion is that fast electron propagation, at a current density and kinetic energy relevant to fast ignition, is far from a solved problem and that target design for fast ignition will have to play a significant role to overcome some of the emerging physical obstacles.