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Fusion Science and Technology
Researchers report fastest purification of astatine-211 needed for targeted cancer therapy
Astatine-211 recovery from bismuth metal using a chromatography system. Unlike bismuth, astatine-211 forms chemical bonds with ketones.
In a recent study, Texas A&M University researchers have described a new process to purify astatine-211, a promising radioactive isotope for targeted cancer treatment. Unlike other elaborate purification methods, their technique can extract astatine-211 from bismuth in minutes rather than hours, which can greatly reduce the time between production and delivery to the patient.
“Astatine-211 is currently under evaluation as a cancer therapeutic in clinical trials. But the problem is that the supply chain for this element is very limited because only a few places worldwide can make it,” said Jonathan Burns, research scientist in the Texas A&M Engineering Experiment Station’s Nuclear Engineering and Science Center. “Texas A&M University is one of a handful of places in the world that can make astatine-211, and we have delineated a rapid astatine-211 separation process that increases the usable quantity of this isotope for research and therapeutic purposes.”
The researchers added that this separation method will bring Texas A&M one step closer to being able to provide astatine-211 for distribution through the Department of Energy’s Isotope Program’s National Isotope Development Center as part of the University Isotope Network.
Details on the chemical reaction to purify astatine-211 are in the journal Separation and Purification Technology.
Y. Sentoku, W. Kruer, M. Matsuoka, A. Pukhov
Fusion Science and Technology | Volume 49 | Number 3 | April 2006 | Pages 278-296
Technical Paper | Fast Ignition | dx.doi.org/10.13182/FST06-A1149
Articles are hosted by Taylor and Francis Online.
In the fast ignition scheme, the compressed core is surrounded by a 1-mm-scale coronal plasma. The critical density where the laser deposits energy is still more than 100 m away from the core. The distance is much longer than the laser focus radius or the core size. This situation raises an important question: How can we couple laser energy to the core from such a distance? One of the techniques that has been proposed to overcome this problem is hole boring by the ponderomotive pressure of the incident laser light. In this paper, the physics related to the laser hole boring, including the parametric instabilities, the channel formation, and the hot electron acceleration by ultraintense laser light, are discussed. The maximum density where the laser can propagate by hole boring is obtained as a function of the intensity. This agrees well with experimental observations, and it is confirmed by numerical simulations. The acceleration mechanism of hot electrons in the magnetic channel is also identified. The hot electrons are characterized by the numerical simulations. In summary, the critical issue of energy coupling in this scheme is raised and discussed.