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Latest News
Researchers report fastest purification of astatine-211 needed for targeted cancer therapy
Astatine-211 recovery from bismuth metal using a chromatography system. Unlike bismuth, astatine-211 forms chemical bonds with ketones.
In a recent study, Texas A&M University researchers have described a new process to purify astatine-211, a promising radioactive isotope for targeted cancer treatment. Unlike other elaborate purification methods, their technique can extract astatine-211 from bismuth in minutes rather than hours, which can greatly reduce the time between production and delivery to the patient.
“Astatine-211 is currently under evaluation as a cancer therapeutic in clinical trials. But the problem is that the supply chain for this element is very limited because only a few places worldwide can make it,” said Jonathan Burns, research scientist in the Texas A&M Engineering Experiment Station’s Nuclear Engineering and Science Center. “Texas A&M University is one of a handful of places in the world that can make astatine-211, and we have delineated a rapid astatine-211 separation process that increases the usable quantity of this isotope for research and therapeutic purposes.”
The researchers added that this separation method will bring Texas A&M one step closer to being able to provide astatine-211 for distribution through the Department of Energy’s Isotope Program’s National Isotope Development Center as part of the University Isotope Network.
Details on the chemical reaction to purify astatine-211 are in the journal Separation and Purification Technology.
R. Keppens, J. W. S. Blokland
Fusion Science and Technology | Volume 49 | Number 2 | February 2006 | Pages 131-138
Technical Paper | Plasma and Fusion Energy Physics - Equilibrium and Instabilities | dx.doi.org/10.13182/FST06-A1112
Articles are hosted by Taylor and Francis Online.
Nuclear fusion research promises to harvest the excess energy carried by energetic neutrons when Deuterium and Tritium hydrogen isotopes are fused together to form -particles. Pressure and density conditions needed for these fusion reactions ensure that these charged constituents, together with the free electrons, form a fully ionized plasma at temperatures of about 100 million Kelvin. Any contact with material walls would instantaneously cool the plasma and must be avoided. In the axisymmetric toroidal vessel of a tokamak, a hot plasma is confined primarily by magnetic Lorentz forces. Strong helical magnetic fields that trace out nested toroidal surfaces help to thermally insulate the plasma from the walls and support it against its own pressure gradient. To lowest order, a fluid model of the equilibrium considers only this force balance in the poloidal cross-section of the tokamak, as expressed analytically by the Grad-Shafranov equation.