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Fusion Science and Technology
Researchers report fastest purification of astatine-211 needed for targeted cancer therapy
Astatine-211 recovery from bismuth metal using a chromatography system. Unlike bismuth, astatine-211 forms chemical bonds with ketones.
In a recent study, Texas A&M University researchers have described a new process to purify astatine-211, a promising radioactive isotope for targeted cancer treatment. Unlike other elaborate purification methods, their technique can extract astatine-211 from bismuth in minutes rather than hours, which can greatly reduce the time between production and delivery to the patient.
“Astatine-211 is currently under evaluation as a cancer therapeutic in clinical trials. But the problem is that the supply chain for this element is very limited because only a few places worldwide can make it,” said Jonathan Burns, research scientist in the Texas A&M Engineering Experiment Station’s Nuclear Engineering and Science Center. “Texas A&M University is one of a handful of places in the world that can make astatine-211, and we have delineated a rapid astatine-211 separation process that increases the usable quantity of this isotope for research and therapeutic purposes.”
The researchers added that this separation method will bring Texas A&M one step closer to being able to provide astatine-211 for distribution through the Department of Energy’s Isotope Program’s National Isotope Development Center as part of the University Isotope Network.
Details on the chemical reaction to purify astatine-211 are in the journal Separation and Purification Technology.
Pei-Jun Cai, Yong-Jian Tang, Lin Zhang, Wei-Dong Wu
Fusion Science and Technology | Volume 49 | Number 1 | January 2006 | Pages 74-78
Technical Paper | dx.doi.org/10.13182/FST06-A1087
Articles are hosted by Taylor and Francis Online.
New-type metallic oxide (M2O3 M = Cr, Al) doped plastic shells used for inertial confinement fusion experiments are fabricated with emulsion techniques. Three different phases of solution (W1, O, and W2) are adopted for the fabrication process. The W1 phase is 1 wt% of sodium lauryl sulfate in water. The W1 phase solution is mixed with a 3 wt% M2O3-PS solution in benzene-dichloroethane (O phase) while stirring. The mixed emulsion (W1/O) is then poured into a 3 wt% aqueous polyvinyl alcohol solution (W2 phase) while stirring. The resulting emulsion (W1/O/W2) is heated to evaporate benzene and dichloroethane, and thus, a solid M2O3-PS shell is formed. The diameter and wall thickness of the shells are 300 and 5 m, respectively. The average surface roughness of the final products is <30 nm. Other parameters, uniformity and sphericity, are 98.9 and 99.6%, similar to or better than that of the usual PS shells.