Workers with Oak Ridge Office of Environmental Management contractor Isotek have surpassed a significant milestone in the supply of medical radioisotopes, extracting more than 15 grams of rare thorium-229 through the Department of Energy’s Thorium Express Project.

TerraPower Isotopes, a subsidiary of Bellevue, Wash.–based TerraPower, announced it is now producing actinium-225 at commercial scale, making the medical isotope available to the pharmaceutical industry through weekly production runs. As a result, TerraPower Isotopes said its actinium, after further manufacturing, is now used in multiple drug developers’ radiopharmaceuticals in human clinical trials across the globe.

QSA Global, a provider of radioisotope products, and Niowave, a Michigan-based producer of medical radioisotopes, announced that the companies will codevelop a scalable radium purification process using Niowave’s radium-226 processing technology to meet the demand for actinium-225, an alpha-emitter used in the treatment of cancer. According to the companies, the strategic partnership marks a significant advancement in the field of radiopharmaceutical technology, enhancing the supply chain for critical radioisotopes, including Ac-225.

Niowave uses a closed-loop cycle to produce high-purity Ac-225 and other alpha emitters from Ra-226 using a superconducting electron linear accelerator. According to the company’s website, the electron beam impinges on a photon converter to irradiate the Ra-226, inducing a photon-neutron reaction to Ra-225, which decays to Ac-225.

The Defense Advanced Research Projects Agency (DARPA) Defense Sciences Office (DSO) wants to mimic and accelerate the natural half-life decay chain of alpha-emitting radioisotopes and plans to invite proposals for experimental or theoretical research tracks under Decay on Demand—a new DARPA disruptioneering opportunity. The solicitation was published in draft form on June 27.

According to the Council on Radionuclides and Radiopharmaceuticals, more than 82,000 nuclear imaging procedures using nuclear medicine are performed throughout the world every day. To administer these vital medical procedures, radiopharmaceutical companies and hospitals rely on a handful of producers of medical radioisotopes.

BWX Technologies subsidiary BWXT Medical has agreed to provide Fusion Pharmaceuticals with generators to produce actinium-225, a medical isotope used to treat cancer in clinical trials.

German-based radiopharmaceutical biotech company ITM Isotope Technologies Munich and Canadian Nuclear Laboratories are launching a new joint venture company for the industrial-scale production of actinium-225, which is used in targeted alpha therapies to fight cancer. The new company is being called Actineer.

The Department of Energy announced on April 11 that it will distribute $1 million to three awardees to evaluate newly developed radioisotopes for potential therapeutic use in preclinical and clinical trials. The funding is provided by the DOE Isotope Program, which produces isotopes for use in science, medicine, and industry that would otherwise be unavailable or in short supply.

An Oak Ridge National Laboratory researcher has built a device that can speed up the separation of the medical radioisotope actinium-225 from irradiated thorium targets and withstand the high-radiation environment of a hot cell. In July, ORNL announced that Kevin Gaddis, a chemistry technician at the lab, had built and tested a prototype and was working to secure a patent for a device that cut separations time by 75 percent.