For in-scope structures, systems, and components (SSCs), applications such as the Licensing Modernization Project (NEI 18-04 Rev. 1) and Reliability Integrity Management (ASME BPVC Section XI Division 2) call for setting low-level reliability targets that collectively satisfy various higher-level risk goals and also satisfy considerations related to defense in depth. In a specific plant design application, given • a PRA, • SSC-level reliability targets, • the associated SSC-level capability requirements assumed in the PRA, and • a good understanding of the stressors and processes that degrade the constituent materials of those SSCs, the processes associated with monitoring and non-destructive examination can be formulated so as to show whether SSC-level targets are being satisfied in operation. If they are not being satisfied, satisfaction of the plant-level goals may be threatened. The reliability targets chosen clearly affect not only the safety case, but also the resource implications of the required monitoring and non-destructive examination. The process of setting reliability targets is not yet standard, and panel discussion of that topic is expected to be fruitful.