The key findings from a suite of independent analyses of the performance of the proposed repository at Yucca Mountain, conducted by the Center for Nuclear Waste Regulatory Analyses (CNWRA) and the U.S. Nuclear Regulatory Commission (NRC), are summarized. The analyses are geared toward obtaining risk insights from deterministic and probabilistic calculations of potential exposure to people in a down-gradient community, determining the capability of barriers to reduce flow of water and prevent or delay radionuclide transport, and identifying models, parameters, and subsystems that have the most influence on repository performance through the use of sensitivity and uncertainty analyses. The analyses have allowed the CNWRA and NRC to focus on the most critical aspects of estimating postclosure repository performance.