Geometrical and spectral differences between inertial confinement fusion (ICF) and magnetic confinement fusion (MCF) facilities lead to significant variation of up to ∼ 60% in peak values and profiles of the time averaged blanket nuclear parameters for the same first wall exposure. Simple scaling of radiation effects with neutron wall loading is inappropriate. These effects together with the temporal effects, that result in ∼ 5 to 8 orders of magnitude higher instantaneous reaction rates in the pulsed ICF reactors, lead to significantly different blanket performances in the ICF and MCF reactor environments.