Inertial electrostatic confinement of ions has been successfully used to achieve conditions necessary for the fusion of advanced fuels, such as 3He. This type of device at the University of Wisconsin was the first to produce steady-state D3He fusion, and has since produced up to 7 × 106 14.7 MeV proton/s from the D3He fusion reaction. The factors influencing the reaction rate and the experimental results are discussed.