Neutronics and activation calculations have been performed for the FIRE design with different first wall design options. Modest values of nuclear heating occur in the machine components. Magnet insulators that have radiation tolerance to 150 MGy should be used. The operational schedule allows for decay of short-lived radionuclides between pulses resulting in low levels of activity and decay heat at shutdown. Additional shielding is provided in midplane ports and at the top of the machine to allow for hands-on maintenance of ex-vessel components.