This study investigates the effects of the material mechanical properties heterogeneity and strength mismatch variation on crack driving forces for cracks in a dissimilar metal welded joint (DMW) of a reactor pressure vessel inlet nozzle to the safe end. Linear elastic and elastic-plastic analyses are carried out to calculate the stress intensity factor (SIF) and J-integral for cracks in the DMW. The effects of crack locations, crack depths, and strength mismatch factors on the SIF and J-integral are studied. The SIF results obtained by finite element analysis are compared with those obtained by the influence function method adopted in the nuclear power code. Results show that the effect of crack location on the SIF can be ignored. The SIFs calculated by the influence function method for cracks in the DMW are basically reasonable, although its conservatism is slightly insufficient. Moreover, with moving the crack location from the nozzle through buttering and weld metal to the safe end, the J-integral increases. The effect of the crack location and strength mismatch factors on the J-integral is essentially caused by variation of the plastic zone and the material properties of the crack front. The crack sizes affect the level of influence of the crack location and the strength mismatch factors on the J-integral. The J-integral increases with decrease of the strength mismatch factor.