As per present models, laser imprint and implosion symmetry are insufficient to account for observed performance degradation of direct-drive cryogenic fusion implosions. More and better data are needed on ablator defects as a source of hydrodynamic instability and mix. To investigate this, a series of OMEGA experimental campaigns is underway to study isolated target defects. Key requirements are systematic variation of the laser intensity and pulse shape at shot, with highly controlled defect type, geometry, and location. Given the need for sub-micron resolution and precise registration of multiple features, two-photon polymerization (TPP) printing was identified as an ideal method to fabricate these targets. TPP printing has enabled controlled formation of designed domes, divots, and vacuoles for studying the combined effect of size and proximity of these features on the hydro performance.