A methodology has been developed for calculating indices of three classes of radiological hazards: reactor accidents, occupational exposures, and waste-disposal hazards. Radionuclide inventories, biological hazard potentials (BHP), and various dose-related indices are calculated. In the case of reactor accidents, the critical, 50-year and chronic dose are computed, as well as the number of early deaths and illnesses and late cancer fatalities. For occupational exposure, the contact dose rate is calculated for several times after reactor shutdown. In the case of waste-disposal hazards, the intruder dose and the intruder hazard potential (IHP) are calculated. Sample calculations for the MARS reactor design show the usefulness of the methodology in exploring design improvements.