Traditional wireless technologies are typically difficult and costly to implement in industrial environments such as nuclear power plants. Because the current implementation methodology is specific to individual wireless protocols such as LTE, Wi-Fi, WirelessHART, and ISA100, each family of wireless devices requires its own antennas, data collection nodes, and supporting infrastructure to move data from the field to a centralized monitoring point in the plant. Furthermore, keeping the system up-to-date often requires expensive overhauls to the electronics to keep up with rapidly changing wireless technologies. Due to increased plant demand for data intensive applications such as equipment condition monitoring, voice and video communication, and access to electronic work packages, nuclear power plants need the ability to upgrade their wireless backbone to handle increased data throughput while protecting against evolving cyber security threats. Distributed Antenna System (DAS) technology has the potential to address the obsolescence and infrastructure issues associated with traditional wireless implementations. A DAS uses a radiating cable and/or collection of antennas to provide wireless coverage to a large area including within and through metallic, concreate, and other objects. A research and development (R&D) project is being conducted to identify and resolve the challenges associated with the use of DAS technology in a nuclear power plant. These challenges include identifying the optimal system components and installation practices that should be used when implementing a DAS in a nuclear power plant to maximize performance, minimize EMI/RFI concerns, and address cyber security and other installation considerations. Furthermore, the R&D project is addressing the lack of wireless condition monitoring sensors capable of communicating over a DAS that meet the needs of the nuclear industry.