This paper focuses on the study and implementation of General Operating Procedure(GOP) of CPR1000 nuclear power plant control room in China. Hong Yan He Nuclear Power Plant (HYH NPP) is on behalf of the first standard technology CPR1000 plants based on the LING AO 3&4 nuclear plants project[4]. Some technical improvements for Main Control Room such as Computerized Operating Procedure Systems (COPS)[5],Backup-Panel(BUP), Large Display Panel (LDP), Advanced alarm system, Safety Parameter Display system(SPDS)were implemented in the LING AO 3&4 NPP[6].. New development for General Procedure of CPR1000 Main Control Room is detailed in this paper. Meanwhile, New I&C systems provide new features that affect the control room operating concept, therefore a detailed analysis is required to take into consideration all the operating and human factor aspects. Any modernization for Control Room such as COPS, that affects what information the operator sees or the system's response to a control input must be empirically evaluated to ensure that the new study does not compromise human-system interaction effectiveness. Based on experience with HYH NPP Units 1&2 in China, this paper presents the approach used as well as the most relevant aspects of this kind of project. This approach will be used in new nuclear power plant, and also used in modernizing I&C system in currently operative nuclear power plants, in addition to meeting safety requirements and the plant's operational requirements, to improve cost-effective plant and human performance and to reduce likelihood of human errors, to gain maximum benefit of the implemented technology and to increase the performance, resulting in improved plant safety, availability, reliability, and cost-effective operation.