The qualification of digital Instrumentation and Control (I&C) platforms for use in systems important to safety at nuclear power plants is needed in order to demonstrate that these I&C platforms are suitable for their intended applications. Evaluation guidance in this area is warranted given the increase use of digital I&C systems in operating and new reactor designs as well as its safety implications. Therefore, this paper provides an evaluation guidance framework for assessing the qualification of a digital I&C platform for use in systems important to safety. The framework addresses the following areas associated with the platform qualification: (1) the scope of qualification; (2) methods of qualification; (3) documentation; (4) the application of the qualification; and (5) the maintenance of the qualification. The methodology discussed by this paper is not to be construed as a requirement, regulation, or acceptable guidance by either domestic or international regulators; instead, it is intended to serve as a potential foundation or technical basis to be used for developing clear and sufficient regulatory guidance for assessing digital I&C platform qualification for use in systems important to safety.