Nuclear power plants are equipped with various safety systems that reduce the frequency of accidents, but the risk of radiation release still exists in the event of an accident. In the event of a radiation release accident, residents near the power plant are evacuated. This study proposes evacuation strategies to minimize radiation exposure. It compares and analyzes the dispersion of radioactive materials and their impact on the population under typical weather conditions and natural disasters like typhoons. Under typical weather conditions, the Keyhole Strategy, based on the Puff model, is applied to establish real-time evacuation zones according to the dispersion area of radioactive materials, demonstrating effective evacuation and reduced radiation exposure. In contrast, during extreme weather conditions such as typhoons, changes make evacuation challenging. In such cases, a strategy of sheltering indoors until the typhoon passes, followed by evacuation, is more effective. This study highlights the potential of utilizing the precision of weather forecasting models and the Puff model to optimize real-time radiation impact assessments and evacuation strategies.