Quantitative validation of a computational fluid dynamics (CFD) code is about making point-to-point comparisons over fields of data to make statements about predictive fidelity. By the very nature of CFD, these comparisons are high-performance computing and data intensive. This presentation provides an overview of workflow development toward quantitative development of two-phase CFD codes. The focus here is on multifield two-fluid model capability implemented in the commercial CFD code ANSYS CFX applicable to boiling gas-liquid two-phase flows. Applications to validating three-dimensional predictions that span two-phase flow regimes are discussed.