A prototype expert system is developed for fuel failure monitoring in Canada deuterium uranium (CANDU) power reactors. Based on a coolant activity analysis, the system is able to provide information in an operating reactor on the number of fuel failures, the average defect size, and the amount of tramp uranium deposited on the in-core surfaces of the primary heat transport system. The fission product release model used in the system is based on results from an in-reactor experimental program at Chalk River Nuclear Laboratories. The expert system is validated against fuel failure data from a number of CANDU power reactors.