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Orano Med inaugurates Pb-212 production facility in Indiana
Guillaume Dureau of Orano Group (left) and Orano Med’s Julien Dodet cut the ribbon on the new ATLabs Indianapolis. (Photo: Orano)
Orano Group subsidiary Orano Med, a developer of targeted alpha therapies for oncology, inaugurated its first ATLab (Alpha Therapy Laboratory) earlier this month. Located in Brownsburg, near Indianapolis, Ind., ATLab Indianapolis is an industrial-scale pharmaceutical facility dedicated to the production of lead-212–based radioligand therapies.
Targeted alpha therapy has shown to be effective in treating various oncological diseases, combining the natural ability of biological molecules to target cancer cells with the short-range cell-killing capabilities of alpha emissions generated by Pb-212. With a half-life of 10.64 hours, along with a decay product of the short-lived alpha-emitter bismuth-212, Pb-212 allows for the possible synthesis and purification of complex radiopharmaceuticals with minimum loss of radioactivity during preparation.
The development of radiopharmaceuticals has long been hampered by the difficulty of manufacturing and distribution on an industrial scale, Orano said, adding that the construction of ATLab Indianapolis is a major step toward making these new treatments available to cancer patients with high unmet needs in North America.
Edward A. Hoffman, Weston M. Stacey
Nuclear Technology | Volume 144 | Number 1 | October 2003 | Pages 83-106
Technical Paper | Radioactive Waste Management and Disposal | doi.org/10.13182/NT03-A3431
Articles are hosted by Taylor and Francis Online.
Fuel cycle analyses are performed to evaluate the impacts of further transmutation of spent nuclear fuel on high-level and low-level waste mass flows into repositories, on the composition and toxicity of the high-level waste, on the capacity of high-level waste repositories, and on the proliferation resistance of the high-level waste. Storage intact of light water reactor (LWR) spent nuclear fuel, a single recycle in a LWR of the plutonium as mixed-oxide fuel, and the repeated recycle of the transuranics in critical and subcritical fast reactors are compared with the focus on the waste management performance of these systems. Other considerations such as cost and technological challenges were beyond the scope of this study. The overall conclusion of the studies is that repeated recycling of the transuranics from spent nuclear fuel would significantly increase the capacity of high-level waste repositories per unit of nuclear energy produced, significantly increase the nuclear energy production per unit mass of uranium ore mined, significantly reduce the radiotoxicity of the waste streams per unit of nuclear energy produced, and significantly enhance the proliferation resistance of the material stored in high-level waste repositories.