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Orano Med inaugurates Pb-212 production facility in Indiana
Guillaume Dureau of Orano Group (left) and Orano Med’s Julien Dodet cut the ribbon on the new ATLabs Indianapolis. (Photo: Orano)
Orano Group subsidiary Orano Med, a developer of targeted alpha therapies for oncology, inaugurated its first ATLab (Alpha Therapy Laboratory) earlier this month. Located in Brownsburg, near Indianapolis, Ind., ATLab Indianapolis is an industrial-scale pharmaceutical facility dedicated to the production of lead-212–based radioligand therapies.
Targeted alpha therapy has shown to be effective in treating various oncological diseases, combining the natural ability of biological molecules to target cancer cells with the short-range cell-killing capabilities of alpha emissions generated by Pb-212. With a half-life of 10.64 hours, along with a decay product of the short-lived alpha-emitter bismuth-212, Pb-212 allows for the possible synthesis and purification of complex radiopharmaceuticals with minimum loss of radioactivity during preparation.
The development of radiopharmaceuticals has long been hampered by the difficulty of manufacturing and distribution on an industrial scale, Orano said, adding that the construction of ATLab Indianapolis is a major step toward making these new treatments available to cancer patients with high unmet needs in North America.
R. Krieg, B. Dolensky, B. Göller, W. Breitung, R. Redlinger, P. Royl
Nuclear Technology | Volume 141 | Number 2 | February 2003 | Pages 109-121
Technical Paper | Reactor Safety | doi.org/10.13182/NT03-3
Articles are hosted by Taylor and Francis Online.
Because hydrogen combustion is one of the major containment threats during severe accidents, different hydrogen mitigation measures have been implemented in nuclear power plants throughout the world. In German Konvoi plants passive autocatalytic recombiners have been selected for hydrogen risk reduction. This paper proposes a new further improved option by taking credit from both the recombiners for hydrogen releases on slow timescales and the large load-carrying capacity of the spherical steel containment for rapid releases. Therefore, the capacity of spherical steel containment shells is investigated in some detail. The hydrogen and steam distribution in the containment is simulated for a rather conservative accident scenario with a rapid hydrogen release; a large hydrogen detonation is assumed and the transient containment loads as well as the structural containment response are calculated. For all these analyses advanced methods with high time and space resolutions are applied.Detailed evaluations of the structural results considering recent experimental findings suggest that the spherical steel containment can carry the detonation loads. For the final assessment additional accident scenarios must be considered and more plant specific finite element models for the structural response must be applied. Some very local integrity issues need further investigations.