A shielded ion microprobe analyzer for elemental and isotopic analyses of irradiated fast reactor fuel and fuel component has been developed and installed in an alpha-gamma hot cell. Radiation shielding of the equipment ensures the radiation dose of <2 mR/h (5.16 × 10−7 C/kg) for 5 Ci (1.85 × 1011 Bq) of a 60Co source. Hot samples can be automatically transferred from the cell to the sample chamber of the analyzer. Contamination inside the equipment through sputtering of the radioactive materials can be reduced with a special device. Distribution and migration of fission products, such as 137Cs, 138Ba, and 90Sr, and of fissile materials, such as 235U and 239Pu in irradiated mixed-oxide fuel, and isotopic ratios of the elements can be obtained very precisely and quickly.