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Orano Med inaugurates Pb-212 production facility in Indiana
Guillaume Dureau of Orano Group (left) and Orano Med’s Julien Dodet cut the ribbon on the new ATLabs Indianapolis. (Photo: Orano)
Orano Group subsidiary Orano Med, a developer of targeted alpha therapies for oncology, inaugurated its first ATLab (Alpha Therapy Laboratory) earlier this month. Located in Brownsburg, near Indianapolis, Ind., ATLab Indianapolis is an industrial-scale pharmaceutical facility dedicated to the production of lead-212–based radioligand therapies.
Targeted alpha therapy has shown to be effective in treating various oncological diseases, combining the natural ability of biological molecules to target cancer cells with the short-range cell-killing capabilities of alpha emissions generated by Pb-212. With a half-life of 10.64 hours, along with a decay product of the short-lived alpha-emitter bismuth-212, Pb-212 allows for the possible synthesis and purification of complex radiopharmaceuticals with minimum loss of radioactivity during preparation.
The development of radiopharmaceuticals has long been hampered by the difficulty of manufacturing and distribution on an industrial scale, Orano said, adding that the construction of ATLab Indianapolis is a major step toward making these new treatments available to cancer patients with high unmet needs in North America.
Mark J. Holowach, Lawrence E. Hochreiter, Fan-Bill Cheung, David L. Aumiller
Nuclear Technology | Volume 140 | Number 1 | October 2002 | Pages 18-27
Technical Paper | Thermal Hydraulics | doi.org/10.13182/NT02-A3320
Articles are hosted by Taylor and Francis Online.
Critical heat flux (CHF) at a low-flow condition in a small-hydraulic-diameter duct is an important phenomenon for a Materials Test Reactor/Advanced Test Reactor (MTR/ATR) design under a number of accident conditions, including reflood transients. Current CHF models in the literature, such as the Mishima/Nishihara and Oh/Englert CHF models, are based on macroscopic system parameters and not local thermal-hydraulic conditions. These macroscopic parameter-based models cannot be readily used for analysis in transient best-estimate thermal-hydraulic codes. The present work focuses on developing a low-flow-rate CHF correlation, based on local conditions, that is amenable to implementation into a best-estimate transient thermal-hydraulic code for a small-hydraulic-diameter duct. The model development proceeds with a means of correlating CHF data to local conditions parameters and then applying a correction factor to the resulting correlation, subsequently permitting accurate predictions over a range of pressures. An evaluation of the proposed local conditions-based CHF model is conducted by predicting independent sets of CHF experimental results over a range of flow rate, pressure, and subcooling conditions. Conclusions on the viability of the proposed CHF model and suggestions for future efforts in improving the reflood heat transfer CHF models for small-hydraulic-diameter ducts are provided with an evaluation of the model results.