A dynamic optimization scheme has been developed to generate high-level-waste (HLW) blending sequences that optimize waste-processing parameters such as raw waste volume processed in a batch, waste-processing time, or waste-processing cost. The optimization algorithm takes advantage of the linear algebraic equation formulation and the continuous-discrete event mapping algorithms used in the Production Planning Model (ProdMod) simulator development. The FORTRAN-based optimizer is interfaced with the SPEEDUP-based dynamic process simulator ProdMod. The optimization scheme has been successfully implemented to maximize the amount of raw waste volume processed in a batch for one of the salt-processing options at the Savannah River Site HLW complex. Parametric studies demonstrate that this optimization scheme provides a realistic approach for guiding the operation of HLW complexes. The optimization scheme is applicable to other sites in the nuclear waste complex (e.g., Hanford) and also for process industries where the dynamics are simulated using Aspen Technology's SPEEDUP software development package.