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Conference Spotlight
Nuclear Energy Conference & Expo (NECX)
September 8–11, 2025
Atlanta, GA|Atlanta Marriott Marquis
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Chris Wagner: The role of Eden Radioisotopes in the future of nuclear medicine
Chris Wagner has more than 40 years of experience in nuclear medicine, beginning as a clinical practitioner before moving into leadership roles at companies like Mallinckrodt (now Curium) and Nordion. His knowledge of both the clinical and the manufacturing sides of nuclear medicine laid the groundwork for helping to found Eden Radioisotopes, a start-up venture that intends to make diagnostic and therapeutic raw material medical isotopes like molybdenum-99 and lutetium-177.
Andrej Prosek, Borut Mavko
Nuclear Technology | Volume 126 | Number 2 | May 1999 | Pages 186-195
Technical Paper | Thermal Hydraulics | doi.org/10.13182/NT99-A2966
Articles are hosted by Taylor and Francis Online.
When best-estimate calculations are performed, uncertainty needs to be quantified. An optimal statistical estimator (OSE) algorithm is adapted, extended, and used for response surface generation to demonstrate the algorithm's applicability to evaluating uncertainties in single-value or time-dependent parameters. A small-break loss-of-coolant accident with the break in the cold leg of a two-loop pressurized water reactor is selected for analysis. The code scaling, applicability, and uncertainty (CSAU) method was used for uncertainty quantification. The uncertainty was quantified for the RELAP5/MOD3.2 thermal-hydraulic computer code.The study shows that an OSE can be efficiently used instead of regression analysis for response surface generation. With the OSE, optimal information obtained from the code calculation is used for response surface generation. This finding indicates that by increasing the number of code calculations, one increases the confidence level of the uncertainty bounds. Increasing the number of calculations also results in convergence of the peak cladding temperature. As uncertainty can be evaluated for time-dependent parameters, the OSE tool makes the CSAU method universal for evaluating uncertainties of transients other than those of a loss-of-coolant accident.