Oxidative attack of stainless-steel cladding in mixed uranium-plutonium oxide fast reactors may limit the life of the fuel pins. Present knowledge of cladding reactions suggests that the key factor in controlling cladding attack may be control of the oxygen potential (ΔḠ = RT ln p) by the insertion of oxygen getters within the fuel pin. Niobium, titanium, and vanadium are prime candidates as oxygen getters because they are easily oxidized at more negative oxygen potentials than the stainless-steel cladding. On the basis of predicted oxidation rates at the low oxygen pressures encountered in fuel pins, the recommended order of getter suitability is V >Nb >Ti.