Isotope effluent data obtained during three instances of experiment failures at the Advanced Test Reactor (ATR) are analyzed to provide an overview of the methods used to detect initial signs of unintended fission product release. The data are contextualized with the operational experience, including means of identification and subsequent mitigation strategies, gained during these events. General trends as well as variations in isotopic behavior among the three failures are explored. Background on the Real Time Monitor, a high-purity germanium detector, and other fission product monitoring systems utilized at the ATR is also provided. The presented analysis was used to establish administrative action levels that are currently utilized by ATR for early detection of experiment fission product release. Early identification provides time to make programmatic decisions before approaching safety and environmental limits.