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Conference Spotlight
Nuclear Energy Conference & Expo (NECX)
September 8–11, 2025
Atlanta, GA|Atlanta Marriott Marquis
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The Standards Committee is responsible for the development and maintenance of voluntary consensus standards that address the design, analysis, and operation of components, systems, and facilities related to the application of nuclear science and technology. Find out What’s New, check out the Standards Store, or Get Involved today!
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Chris Wagner: The role of Eden Radioisotopes in the future of nuclear medicine
Chris Wagner has more than 40 years of experience in nuclear medicine, beginning as a clinical practitioner before moving into leadership roles at companies like Mallinckrodt (now Curium) and Nordion. His knowledge of both the clinical and the manufacturing sides of nuclear medicine laid the groundwork for helping to found Eden Radioisotopes, a start-up venture that intends to make diagnostic and therapeutic raw material medical isotopes like molybdenum-99 and lutetium-177.
R. Accorsi, M. Marseguerra, E. Padovani, E. Zio
Nuclear Science and Engineering | Volume 132 | Number 3 | July 1999 | Pages 326-336
Technical Paper | doi.org/10.13182/NSE99-A2067
Articles are hosted by Taylor and Francis Online.
In real, complex plants, a sensitivity analysis of the effects that variations in the plant inputs and design parameters have on the outputs is of great importance both from the point of view of productivity and of safety. To a first approximation, sensitivity analysis consists of estimating the partial derivatives of the outputs with respect to the varied quantities. These derivatives cannot be obtained on the real plant directly since the effects of all the involved variables are intermixed. Therefore, one has to resort to suitable computational models and algorithms.A new neural network approach that aims at creating a differentiable copy of the plant is proposed. A feature of the method is that the data for network training are collected with the system in nominal operation: This represents, indeed, a fundamental constraint for all risky plants, for which unrestrained playing is definitely not recommended. The sensitivity coefficients (partial derivatives) thereby obtained are applied for the regulation of the reactivity of a simulated pressurized water reactor in response to changes in the electric load at the power grid, so as to maintain the average temperature of the water in the reactor core at a constant value.