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Conference Spotlight
Nuclear Energy Conference & Expo (NECX)
September 8–11, 2025
Atlanta, GA|Atlanta Marriott Marquis
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The Standards Committee is responsible for the development and maintenance of voluntary consensus standards that address the design, analysis, and operation of components, systems, and facilities related to the application of nuclear science and technology. Find out What’s New, check out the Standards Store, or Get Involved today!
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Chris Wagner: The role of Eden Radioisotopes in the future of nuclear medicine
Chris Wagner has more than 40 years of experience in nuclear medicine, beginning as a clinical practitioner before moving into leadership roles at companies like Mallinckrodt (now Curium) and Nordion. His knowledge of both the clinical and the manufacturing sides of nuclear medicine laid the groundwork for helping to found Eden Radioisotopes, a start-up venture that intends to make diagnostic and therapeutic raw material medical isotopes like molybdenum-99 and lutetium-177.
Y. Richet, G. Caplin, J. Crevel, D. Ginsbourger, V. Picheny
Nuclear Science and Engineering | Volume 175 | Number 1 | September 2013 | Pages 1-18
Technical Paper | doi.org/10.13182/NSE11-116
Articles are hosted by Taylor and Francis Online.
Nuclear criticality safety assessment often requires groupwise Monte Carlo simulations of k-effective in order to check subcriticality of the system of interest. A typical task to be performed by safety assessors is hence to find the worst combination of input parameters of the criticality Monte Carlo code (i.e., leading to maximum reactivity) over the whole operating range. Then, checking subcriticality can be done by solving a maximization problem where the input-output map defined by the Monte Carlo code expectation (or an upper quantile) stands for the objective function or “parametric” model. This straightforward view of criticality parametric calculations complies with recent works in Design of Computer Experiments, an active research field in applied statistics. This framework provides a robust support to enhance and consolidate good practices in criticality safety assessment. Indeed, supplementing the standard “expert-driven” assessment by a suitable optimization algorithm may be helpful to increase the reliability of the whole process and the robustness of its conclusions. Such a new safety practice is intended to rely on both well-suited mathematical tools (compliant optimization algorithms) and computing infrastructure (a flexible grid-computing environment).