The Transuranium Processing Plant will isolate the transuranium elements produced by the irradiation of Pu242 and Am243-Cm244 in the High Flux Isotope Reactor presently under construction at ORNL. The facility is designed for the production and cumulative storage of up to 4 gm of Cf252 which will be ultimately employed for research purposes. The facility will consist of nine heavily shielded process cells and eight laboratories. The toxicity of the heavier transuranium elements justifies a refined building containment and ventilation system. The building is scheduled for full-scale operation by December, 1965, at an estimated cost of $8.7 million.