High-energy-density (HED) experiments utilizing X-ray free electron lasers (XFELs) must take a different approach to fielding these experiments than the current methodology used for the large HED facilities in the United States. The XFELs and their associated laser drivers have a much faster repetition rate than do the larger facilities. Experiments must be designed to execute hundreds rather than a few shots per experimental run. The new paradigm requires a different approach to data collection and analysis. It also requires an integrated approach to experiment and target design. In this study, we developed new target designs for a future XFEL experiment that meet both experiment and cost goals.