Two different, complementary approaches were taken to determine the effects of an Inertial Electrostatic Confinement (IEC) grid's design on the neutron production rate of the device. A semi-empirical formula developed from experimental data predicts the neutron yield of an IEC device, given the chamber size, grid radius and transparency, and operating voltage and current. Results from the IXL™ computer program support some of the scalings found in the semi-empirical formula. A second formula was also developed that predicts the neutron yield of an IEC device using grid design parameters and the ion core radius. The SIMION™ computer program was used to calculate the ion core radius. These formulas are useful tools for designing grids that will maximize the neutron yield for IEC devices.