A materials testing scenario was developed to determine the effects of irradiation on five key material properties needed for fusion reactor design. These properties, tensile strength, fracture toughness, irradiation creep, fatigue, and swelling, were selected after consideration of the most likely failure modes to occur in a fusion reactor. Three structural materials were chosen for investigation: PCA, HT-9, and V-15Cr-5Ti. A total of 10,104 specimens were specified for irradiation, but initially only 1246 specimens would be tested. The entire testing scenario can be completed in 5-1/2 years in existing facilities.