The fracture strength was estimated for copper-alloy CuCrZr, and their HIPed joints with SS316L and CuCrZr, which were the candidate materials consisting of the First Wall of ITER. Fracture toughness and fatigue crack propagation ratio of those materials were superior to those of copper-alloy DS-Cu and its HIPed joint with SS316. It was confirmed that the cracks near the CuCrZr/SS316L HIPed boundary was propagated in copper-alloy along the interface at a distance of about 10m from the interface. The lost of ductility of all materials caused the decrement of fracture toughness and increment of crack propagation ratio in high temperature (573K).