A study on the activation of the Ignitor machine is performed. The machine has been modelled with the neutron transport code ANISN, in orderto calculate the neutron fluxes. These have been input in the inventory code ANITA, and the neutron-induced radioactivity in the structures of the machine is obtained. It becomes clear that the activation of certain parts of the machine (vessel, magnets) requires the adoption of remote handling equipment for their maintenance. The substitution of INCONEL 625 (vessel material for Ignitor) by a material with lower long-term activation is discussed.