A safety evaluation of the Tritium Removal Facility (TRF), constructed at the Darlington Nuclear Generating Station site is presented. This assessment focusses on the principal hazards associated with the facility, and the role of safety features in mitigating the consequences of any release of tritium. Additionally, the hydrogen explosion and fire hazards have been examined in detail to provide the assurance that the consequences of co-location of the TRF, in close proximity (∼100 m) to critical structures of the station, would not jeopardize the safe operation and shutdown of the reactors following a failure at the TRF.