One of the primary objectives of the Tritium Systems Test Assembly is to demonstrate that the technologies associated with the DT fuel cycle for a fusion reactor can be operated safely and operated with minimal environmental impact. During the design and construction phase, safety analyses were performed to investigate the effects of normal operations, of component failure, of operational failures, and of failures induced by natural phenomena. The effects on operation personnel, the general public and the environment were determined. Major releases of tritium were found to be highly improbable (<10−6/year) since they require a compound failure of primary and secondary containment, along with either a breach of the building or a failure of the room cleanup system. The effects from normal operations and high probability failures were also determined to be minimal.