Sandia National Laboratories has initiated a scoping level design of a sub-critical transmutation reactor driven by Z-Pinch fusion. The baseline design is able to burn up 1,280 kg of actinides per year while at the same time producing 3,000 MWth. The fusion driver required for this application is 20 MW, or a 200 MJ target fired once every 10 seconds. This paper discusses how a fusion actinide burner can fit into the nuclear fuel cycle.