An overview of the diagnostics installed on the Alcator C-Mod tokamak is presented. Approximately 25 diagnostic systems are being operated on C-Mod. The compact design of the machine and the cryostat enclosing the vacuum vessel and magnetic field coils make access challenging. Diagnostics are used to study four focus areas: transport, plasma boundary, waves, and macrostability. There is significant overlap between these topics, and they all contribute toward the burning plasma and advanced tokamak thrusts. Several advanced and novel diagnostics contribute to the investigation of C-Mod plasmas, e.g., electron cyclotron emission, phase-contrast imaging, gas puff imaging, probe measurements, and active magnetohydrodynamic antennas.